Shields up: the Tup1-Cyc8 repressor complex blocks coactivator recruitment.
نویسندگان
چکیده
The Tup1-Cyc8 complex is responsible for repression of a large and diverse collection of genes in Saccharomyces cerevisiae. The predominant view has been that Tup1-Cyc8 functions as a corepressor, actively associating with regulatory proteins and organizing chromatin to block transcription. A new study by Wong and Struhl in this issue of Genes & Development (pp. 2525-2539) challenges nearly 20 years of models by demonstrating that Tup1-Cyc8 functions primarily as a shield to block DNA-binding proteins from recruiting transcriptional coactivators.
منابع مشابه
The Cyc8-Tup1 complex inhibits transcription primarily by masking the activation domain of the recruiting protein.
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ورودعنوان ژورنال:
- Genes & development
دوره 25 23 شماره
صفحات -
تاریخ انتشار 2011